TRANSLATIONALE ENTZÜNDUNGSFORSCHUNG

Publikationen

2024

 

  1. Seyrek K, Ivanisenko N, König C, Lavrik IN. Modulation of extrinsic apoptotic pathway by intracellular glycosylation. Trends in Cell Biology. 2024 February. doi: 10.1016/j.tcb.2024.01.003
  2. Wohlfromm F, Ivanisenko N, Pietkiewicz S, König C, Seyrek K, Kähne T, Lavrik IN Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks. 2024 May, doi: 10.1038/s41388-024-03049-6
  3. König C, Ivanisenko N, Hillert-Richter L, Namjoshi D, Natu K, Espe J, Reinhold D, Kolchanov N, Ivanisenko V, Kähne T, Bose K and Lavrik IN, Targeting type I DED interactions at the DED filament serves as a sensitive switch for cell fate decisions. Cell Chemical Biology, 2024, July doi:10.1016/j.chembiol.2024.06.014
  4. Seyrek K, Espe J, Reiss E, Lavrik IN. The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System. 2024, November doi: 10.3390/cells13211814

 

 

2023

 

  1. Vitale I, Pietrocola F, Guilbaud E, Aaronson SA, Abrams JM, Adam D, Agostini M, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Aqeilan RI, Arama E, Baehrecke EH, Balachandran S, Bano D, Barlev NA, Bartek J, Bazan NG, Becker C, Bernassola F, Bertrand MJM, Bianchi ME, Blagosklonny MV, Blander JM, Blandino G, Blomgren K, Borner C, Bortner CD, Bove P, Boya P, Brenner C, Broz P, Brunner T, Damgaard RB, Calin GA, Campanella M, Candi E, Carbone M, Carmona-Gutierrez D, Cecconi F, Chan FK, Chen GQ, Chen Q, Chen YH, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Ciliberto G, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Daugaard M, Dawson TM, Dawson VL, De Maria R, De Strooper B, Debatin KM, Deberardinis RJ, Degterev A, Del Sal G, Deshmukh M, Di Virgilio F, Diederich M, Dixon SJ, Dynlacht BD, El-Deiry WS, Elrod JW, Engeland K, Fimia GM, Galassi C, Ganini C, Garcia-Saez AJ, Garg AD, Garrido C, Gavathiotis E, Gerlic M, Ghosh S, Green DR, Greene LA, Gronemeyer H, Häcker G, Hajnóczky G, Hardwick JM, Haupt Y, He S, Heery DM, Hengartner MO, Hetz C, Hildeman DA, Ichijo H, Inoue S, Jäättelä M, Janic A, Joseph B, Jost PJ, Kanneganti TD, Karin M, Kashkar H, Kaufmann T, Kelly GL, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Kluck R, Krysko DV, Kulms D, Kumar S, Lavandero S, Lavrik IN, Lemasters JJ, Liccardi G, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Luedde T, MacFarlane M, Madeo F, Malorni W, Manic G, Mantovani R, Marchi S, Marine JC, Martin SJ, Martinou JC, Mastroberardino PG, Medema JP, Mehlen P, Meier P, Melino G, Melino S, Miao EA, Moll UM, Muñoz-Pinedo C, Murphy DJ, Niklison-Chirou MV, Novelli F, Núñez G, Oberst A, Ofengeim D, Opferman JT, Oren M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pentimalli F, Pereira DM, Pervaiz S, Peter ME, Pinton P, Porta G, Prehn JHM, Puthalakath H, Rabinovich GA, Rajalingam K, Ravichandran KS, Rehm M, Ricci JE, Rizzuto R, Robinson N, Rodrigues CMP, Rotblat B, Rothlin CV, Rubinsztein DC, Rudel T, Rufini A, Ryan KM, Sarosiek KA, Sawa A, Sayan E, Schroder K, Scorrano L, Sesti F, Shao F, Shi Y, Sica GS, Silke J, Simon HU, Sistigu A, Stephanou A, Stockwell BR, Strapazzon F, Strasser A, Sun L, Sun E, Sun Q, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Troy CM, Turk B, Urbano N, Vandenabeele P, Vanden Berghe T, Vander Heiden MG, Vanderluit JL, Verkhratsky A, Villunger A, von Karstedt S, Voss AK, Vousden KH, Vucic D, Vuri D, Wagner EF, Walczak H, Wallach D, Wang R, Wang Y, Weber A, Wood W, Yamazaki T, Yang HT, Zakeri Z, Zawacka-Pankau JE, Zhang L, Zhang H, Zhivotovsky B, Zhou W, Piacentini M, Kroemer G, Galluzzi L. Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death Differ. 2023 April . doi: 10.1038/s41418-023-01153-w 
  2. Dunsche L, Ivanisenko N, Riemann S, Schindler S, Beissert S, Angeli C, Kreis S, Tavassoli M, Lavrik I, Kulms D. A cytosolic mutp53 (E285K) variant confers chemoresistance of malignant melanoma. Cell Death and Disease. 2023 December. doi:10.1038/s41419-023-06360-4.
  3. Wohlfromm F, Seyrek K, Ivanisenko N, Troitskaya O, Kulms D, Richter V, Koval O, Lavrik IN. RL2 Enhances the Elimination of Breast Cancer Cells by Doxorubicin. Cells. 2023 December. doi: 10.3390/cells12242779

2022

 

  1. Seyrek K, Ivanisenko NV, Wohlfromm F, Espe J, Lavrik IN. Impact of human CD95 mutations on cell death and autoimmunity: a model. Trends Immunol. 2022 Jan. doi: 10.1016/j.it.2021.11.006
  2. Seyrek K, Wohlfromm F, Espe J, Lavrik I.N. The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies? Biochemical Journal. 2022 July. doi: 10.1042/BCJ20210676
  3. Espe J, Ivanisenko NK, Hillert-Richter LK, Ivanisenko VA, Lavrik IN. Development of small molecules targeting procaspase-8 at the DISC. Cell and tissue biology. 2022 October. doi:10.1134/S1990519X22050017

2021

 

  1. Wohlfromm F, Richter M, Otrin L, Seyrek K, Vidakovic-Koch T, Kuligina E, Richter V, Koval O, Lavrik IN. Interplay Between Mitophagy and Apoptosis Defines a Cell Fate Upon Co-treatment of Breast Cancer Cells With a Recombinant Fragment of Human Κ-Casein and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. Front. Cell Dev. Biol. 2021 Jan 18. doi: 10.3389/fcell.2020.617762
  2. Evdokimov A, Popov A, Ryabchikova E, Koval O, Romanenko S, Trifonov V, Petruseva I, Lavrik I, Lavrik O. Uncovering molecular mechanisms of regulated cell death in the naked mole rat. Aging. 2021 jan. 28. doi: 10.18632/aging.202577
  3. Lavrik IN. Editorial: Dynamical Networks of Life/Death Decisions in a Cell: From DNA Repair to Cell Death. Front Cell Dev Biol. 2021 Jul. 16. doi: 10.3389/fcell.2021.722426
  4. Hillert-Richter LK, Lavrik IN. Measuring Composition of CD95 Death-Inducing Signaling Complex and Processing of Procaspase-8 in this Complex. J Vis Exp. 2021 Aug. 2. doi 10.3791/62842.PMID: 34398143
  5. Ivanisenko NV, Seyrek K, Hillert-Richter LK, König C, Espe J, Bose K, Lavrik IN, Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer nertworks. Trends Cancer. 2021 Dec. 29. doi 10.1016/j.trecan.2021.12.002. PMID 3497357

 

2020

  1. Hillert LK, Ivanisenko NV, Busse D, Espe J, König C, Peltek SE, Kolchanov NA, Ivanisenko VA, Lavrik IN.Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer. Cell Death Fiffer. 2020 Jan.20. doi: 10.1038/s41418-020-0489-0.
  2. Seyrek K, Ivanisenko NV, Richter M, Hillert LK, König C, Lavrik IN. Controlling Cell Death through Post-translational Modifications of DED Proteins. Trends Cell Biol. 2020 May 30. doi 10.1016/j.tcb2020.02.006
  3. Richter M, Wohlfromm F, Kähne T, Bongartz H, Seyrek K, Kit Y, Chinak O, Richter VA, Koval OA, Lavrik IN. The Recombinant Fragment of Human K-Casein Induces Cell Death by Targeting the Proteins of Mitochondrial Import in Breast Cancer Cells.Cancers. 2020 May 31. doi 10.3390/cancers12061427  
  4. Shah A, Plaza-Sirvent C, Weinert S, Buchbinder JH, Lavrik IN, Mertens PR, Schmitz I, Lindquist JA. YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulationg NF-KB Activation. Cancers. 2020 Aug. 5. doi: 10.3390/cancers12082188
  5. Ivanisenko NV, Seyrek K, Kolchanov NA, Ivanisenko VA, Lavrik IN. The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications. Cell Death Discov. 2020.Oct.10. doi: 10.1038/s41420-020-00331-w
  6. Ivanisenko NV, Lavrik IN. Mathematical Modeling Reveals the Importance of the DED Filament Composition in the Effects of Small Molecules Targeting Caspase-8/c-FLIPL Heterodimer. Biochemistry. 2020. Oct. doi: 10.1134/S0006297920100028.
  7. König C, Hillert-Richter LK, Ivanisenko NV, Ivanisenko VA, Lavrik IN. Pharmacological targeting of c-FLIPL and Bcl-2 family members promotes apoptosis in CD95L-resistant cells. Sci Rep. 2020 Nov. 30. doi: 10.1038/s41598020-76079-1

2019

 

  1. Hillert LK, Bettermann-Bethge K, Nimmagadda SC, Fischer T, Naumann M, Lavrik IN. Targeting RIPK1 in AML cells carrying FLT3-ITD. Int J Cancer. 145 (6): DOI 10.1002/ijc. 32246 Epub 2019 March.
  2. Hillert LK, Ivanisenko NV, Espe J, König C, Ivanisenko VA, Kähne T, Lavrik IN. Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly. Oncogene. 2019 Nov 18. doi: 10.1038/s41388-019-1100-3.
  3. Bagamanshina AV, Troitskaya OS, Nushtaeva AA, Yunusova AY, Starykovych MO, Kuligina EV, Kit YY, Richter M, Wohlfromm F, Kähne T, Lavrik IN, Richter VA, Koval OA. Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors. Biomed Res Int. 2019 Jun 17;2019:4087160. doi: 10.1155/2019/4087160. eCollection 2019.
  4. Saik, O. V., Nimaev, V. V., Usmonov, D. B., Demenkov, P. S., Ivanisenko, T. V., Lavrik, I. N. and Ivanisenko, V. A. (2019). Prioritization of genes involved in endothelial cell apoptosis by their implication in lymphedema using an analysis of associative gene networks with ANDSystem. BMC medical genomics. 12, 47 DOI: 10.1186/s12920-019-0492-9.
  5. Seyrek, K. and Lavrik, I. N. (2019). Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks. Apoptosis : an international journal on programmed cell death. 24, 385-394 DOI: 10.1007/s10495-019-01540-0
  6. Seyrek, K., Richter, M. and Lavrik, I. N. (2019). Decoding the sweet regulation of apoptosis: the role of glycosylation and galectins in apoptotic signaling pathways. Cell death and differentiation. 26, 981-993 DOI: 10.1038/s41418-019-0317-6.
  7. Ivanisenko NV, Buchbinder JH, Espe J, Richter M, Bollmann M, Hillert LK, Ivanisenko VA, Lavrik IN. Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes. BMC Genomics. 2019 May 8;20(Suppl 3):293. doi: 10.1186/s12864-019-5539-y.
  8. Ivanisenko, N. V. and Lavrik, I. N. (2019). [Mechanisms of Procaspase-8 Activation in the Extrinsic Programmed Cell Death Pathway]. Molekuliarnaia biologiia. 53, 830-837 DOI: 10.1134/s0026898419050094.
  9. Manko, N., Starykovych, M., Bobak, Y., Stoika, R., Richter, V., Koval, O., Lavrik, I., Horák, D., Souchelnytskyi, S. and Kit, Y. (2019). The purification and identification of human blood serum proteins with affinity to the antitumor active RL2 lactaptin using magnetic microparticles. Biomedical chromatography : BMC. 33, e4647 DOI: 10.1002/bmc.4647.

2018

 

  1. Pischel D, Buchbinder JH, Sundmacher K, Lavrik IN, Flassig RJ. A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data. PLoS One. 13(5):  DOI: 10.1371/journal.pone.0197208. eCollection 2018.
  2. Buchbinder JH, Pischel D, Sundmacher K, Flassig RJ, Lavrik IN. Quantitative single cell analysis uncovers the life/death decision in CD95 network. PLoS Comput Biol.14(9): DOI 10.1371/journal.pcni.10006368. eCollection 2018 Sep.

2017

  1. Pietkiewicz S, Wolfe C, Buchbinder JH and Lavrik IN. Measuring Procaspase-8 and -10 Processing upon Apoptosis Induction. Bio-protocol 7(1): e2081. DOI: 10.21769/BioProtoc.2081

  2. Zamaraev AV, Kopeina GS, Prokhorova EA, Zhivotovsky B, Lavrik IN. Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. Trends Cell Biol. 2017 May;27(5):322-339. doi: 10.1016/j.tcb.2017.01.003

  3. Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schlüter D, Lavrik IN, Naumann M. Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017 Jun 2. doi: 10.1038/cdd.2017.89

  4. Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A7. A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development. Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010 

2016

  1. Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun. 2016 Mar 16;4(1):25.

  2. Schleich K, Buchbinder JH, Pietkiewicz S, Kähne T, Warnken U, Öztürk S, Schnölzer M, Naumann M, Krammer PH, Lavrik IN. 2015. Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. 2016 Apr;23(4):681-94.

  3. Zimmer C, Schleich K, Lavrik I. Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response. Mol Biosyst. 2016 Apr 26;12(5):1486-95

  4.  Just S, Nishanth G, Buchbinder JH, Wang X, Naumann M, Lavrik I, Schlüter D. A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection. Sci Rep. 2016 Dec 22;6:39796.

2015

  1. Popik OV, Petrovskiy ED, Mishchenko EL, Lavrik IN, Ivanisenko VA. 2015. Mosaic gene network modelling identified new regulatory mechanisms in HCV infection. Virus Res. 2015 Oct 22.

  2. Boehme JD, Pietkiewicz S, Lavrik I, Jeron A, Bruder D. 2015. Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. Lung. 2015 Dec;193(6):947-953

  3. Pietkiewicz S, Eils R, Krammer PH, Giese N, Lavrik IN. 2015. Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network. Exp Cell Res. 2015 Oct 8.

  4. Prokhorova EA, Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN. 2015. Role of the nucleus in apoptosis: signaling and execution. Cell Mol Life Sci. 2015 Dec;72(23):4593-612.

  5. Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN. 2015. Cell death controlling complexes and their potential therapeutic role. Cell Mol Life Sci. 2015 Feb;72(3):505-17

  6. Pietkiewicz S, Schmidt JH, Lavrik IN. 2015. Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining. J Immunol Methods. 2015 Aug;423:99-103

  7. Schmidt JH, Pietkiewicz S, Naumann M, Lavrik IN. 2015. Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level. J Immunol Methods. 2015 Aug;423:12-7.

  8. Petrovskiy ED, Saik OV, Tiys ES, Lavrik IN, Kolchanov NA, Ivanisenko VA. 2015. Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain. BMC Genomics. 2015 Dec 16;16 Suppl 13:S3.

2014

  1. Popik OV, Saik OV, Petrovskiy ED, Sommer B, Hofestädt R, Lavrik IN, Ivanisenko VA. 2014. Analysis of signaling networks distributed over intracellular compartments based on protein-protein interactions. BMC Genomics. 15 Suppl 12:S7

  2. Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. 2014. PDK1 controls upstream PI3K expression and PIP3 generation. Oncogene. 5;33(23):3043-53

  3. Bettermann K, Hohensee T, Haybaeck J. 2014. Steatosis and steatohepatitis: complex disorders. Int J Mol Sci. 2014 Jun 3;15(6):9924-44

  4. Lavrik IN. 2014. Systems biology of death receptor networks: live and let die. Cell Death Dis. 5:e1259

  5. Lavrik IN, Zhivotovsky B. 2014. Systems biology: a way to make complex problems more understandable. Cell Death Dis. 5:e1259

2013

  1. Schleich K, Lavrik IN. 2013. Mathematical modeling of apoptosis. Cell Commun Signaling 11:44.

  2. Schleich K, Krammer PH, Lavrik IN. 2013. The chains of death: A new view on caspase-8 activation at the DISC. Cell Cycle 12:193-194.

  3. Warnken U, Schleich K, Schnölzer M, Lavrik IN. 2013. Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC). Cells 2: 476-495.

  4. Schleich K, Lavrik, IN. Systems Biology of Death Receptor-Induced Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.33-57. 2013.

  5. Rickert D, Fricker N, Lavrik IN, Theis FJ. Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p 57-84. 2013

  6. Fricker N, Lavrik IN. Modeling Single Cells in Systems Biology. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.145-162. 2013.

  7. Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. 2013 PDK1 controls upstream PI3K expression and PIP3 generation. Oncogene. 2013 Jul 29. doi: 0.1038/onc.2013.266

  8. Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU. 2013. Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors. PLoS One. 2013 Apr 11;8(4):e61438. doi: 10.1371/journal.pone.0061438.

  9. Lavrik IN, editor, book 'Systems biology of apoptosis'. Publ. Springer. 2013.

  10. Öztürk S, Schleich K, Lavrik IN. CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase). Atlas Genet Cytogenet Oncol Haematol. November 2013

2012

  1. Schleich K, Warnken U, Fricker N, Oztürk S, Richter P, Kammerer K, Schnölzer M, Krammer PH, Lavrik IN. 2012. Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model. Mol Cell. 47:306-319.

  2. Oztürk S, Schleich K, Lavrik IN. 2012. Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp Cell Res 318:1324-1331.

  3. Lavrik IN, Krammer PH. 2012. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ.1:36-41.

PubMed

www.ncbi.nlm.nih.gov/pubmed?term=lavrik%20i

Presse

www.med.uni-magdeburg.de/Pressestelle/Pressemitteilungen/Mitteilungen+2012/Lavrik-p-20005034.html

Letzte Änderung: 14.11.2024 - Ansprechpartner:

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