News
2024
November, 2024
July, 2024
Fabian Wohlfromm has defended his doctorla defence successfull. Congratulations Fabian!
July, 2024
Our Manuscript about type I DED interactions at the DED filaments is highlighted in press releases.
MDR
OVGU
July, 2024
We are happy that our Manuscript 'Targeting type I DED interactions at the DED filaments serves as a sensitive for cell fate decisions' is published at Cell Chemical Biology' Congratulations to Corinna, Nikita and all authors!
July, 2024
Fabian Wohlfromm's doctoral defence will take place on 15.07.2024 in House 91 Room 001 on the campus of the Faculty of Medicine.
June, 2024
Our group took part at the presentation series of GCI at the medical faculty in Magdeburg. After short introduction by Prof. Inna Lavrik, Nikita, Corinna and Fabian presented their newest data.
May, 2024
Our work about 'arginine-methylation at caspase-8' was highlighted at a press-release:
Medizinische Fakultät/Universitätsklinikum Magdeburg A. ö. R. - Magdeburger Forschungsteam entdeckt wichtige Schaltstelle für das Überleben von Zellen (uni-magdeburg.de)
May, 2024
We are delighted to identify two highly conservative arginine residues in caspase-8 that may undergo symmetric methylation. Find more details in our recent manuscript by Wohlfromm, Ivanisenko et al: Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks
April, 2024
We are very proud to run the special issue in Frontries in Cell Death on
April, 2024
We are very proud to run the special issue in Cells
Cells | Special Issue : Apoptosis in Cancers (mdpi.com)
January, 2024
Elisabeth Reiß has given her defence of master-thesis. Congratulation to Elisabeth!
Elisabeth and her supervisor Johannes
2023
December , 2023
At the end of the year our RL2 manuscript 'RL2 Enhances the Elimination Breast Cancer Cells by Doxorubicin' is published at 'Cells'. Congratulations to Fabian, as well as our cooperation partners.
November , 2023
Prof. Dr. Inna Lavrik was awarded to the Editorial Board Award of the journal "Frontiers in Cell Death and Survival". She was appointed as "Outstanding Associate editor of the Year 2023".
September , 2023
Our AG took part in the organization of ECDO-2023 in Paris at Institut Pasteur. Prof. Lavrik was invited to present our work.
July , 2023
We took part of the yearly Running-Event in Magdeburg. Our Team achieved a great time (1:17:38) and got a nice placement as mixed-team.
June , 2023
AG TEF is proud to host the Cells webinar: 'Quantitative Understanding of Apoptotic and Non-Apoptotic Signaling,' which takes plase on 15.06.2023 at 10 am.
June , 2023
Our research group took part at EWCD conference in Fiuggi, Italy. While Corinna presented her research in a presentation, Johannes and Fabian had diverse discussions during their poster presentations.
May , 2023
Laura Hillert-Richter has given her PhD-Thesis defence. She did an amazing presentation and work. We are very proud of you !
May , 2023
Prof. Dr Kirill Rosen from the 'Department of Biochemistry and Molecular Biology' at the Dalhousie University in Halifax (Canada) has given a Seminar about 'Anoikis at the roads of life and death in breast cancer cells'.
February , 2023
Pia Grimpe has given her defence of master-thesis about 'Uncovering the role of DED-proteins procaspase-8 and c-FLIP in the extrinsic pathway of apoptosis'. Congratulation to Pia!
January , 2023
Our group served as topic editor in the special collection 'Dynamical Networks of Life/Death Decisions in a Cell' in 'Frontiers in Cell and Developmental Biology': Dynamical Networks of Life/Death Decisions in a Cell: From DNA Repair to Cell Death | Frontiers Research Topic (frontiersin.org)
2022
September , 2022
Our group took an active part at the ECDO-meeting this Year. Furthermore, Fabian gave a presentation about 'Recombinant lactaptin analogon RL2 inhibits TRAIL-induced cell death in breast cancer cell lines by mitophagy'.
August , 2022
We are part of the Organization Team of the yearly ECDO conference in Bonn:
ECDO2022
July , 2022
Our Review ' The cross-talk of autophagy and apoptosis in breast carcinoma: implications for novel therapies?' is published in Biochemical Journal. Congratulations to all Authors!
June / July , 2022
Our group took part of the EWCD-conference in Fiuggy, Italy. Corinna and Fabian presented their data in oral presentations, while Johannes have shown his research by a poster.
June, 2022
We took part of the yearly Running-Event in Magdeburg. Our Team achieved a great time and especially Pia Grimpe did a fantastic job as fastest runner.
June, 2022
We are proud that our activities at ECDO (European Cell Death Organization) are highlighted by Press Release of Medical Faculty.
June, 2022
We are very proud that abstracts of Corinna König and Fabian Wohlfromm were selected for oral presentation and the abstract by Johannes Espe was selected for the poster presentation at EWCD in italy:
EWCD | European Workshops on Cell Death
June, 2022
Our Group took part at "Long Night of Science" in Magdeburg. We could give an interactive view in our research and Fabian gave a presentation about the programmed cell death.
March, 2022
We are proud to invite all our colleagues to contribute to the Special Issue:
Systems Biology of Apoptotic and Non- Apoptotic Signaling
January, 2022
New Year, new Review: Our Review 'Impact of human CD95 mutations on cell death and autoimmunity: a model' has been accepted in 'Trends in Immunology. Congratulations to everybody for a good start into the year!
2021
December, 2021
Our Review 'Regulation of extrinsic apoptotic signaling by c-FLIP: towards targeting cancer networks' has been accepted has in 'Trends in cancer'. Congratulations to everybody!
July, 2021
Our manuscript 'Measuring composition of the CD95 DISC and processing of procaspase-8 in this complex' has been accepted for publication by JoVe. Congratulations to Laura!
2020
December, 2020
At the end of the year our second RL2 manuscript 'Interplay Between Mitophagy and Apoptosis Defines a Cell Fate Upon Co-treatment of Breast Cancer Cells With a Recombinant Fragment of Human Κ-Casein and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand' has been accepted in 'Frontiers in Cell and Developmental Biology '. Congratulations to Fabian and Max, as well as our cooperation partners.
October, 2020
Another of our manuscripts with the title ''Pharmacological targeting of c-FLIPL and Bcl-2 family members promotes apoptosis in CD95L-resistant cells" has been accepted for the publication in 'Scientific reports'.
Congratulation to Corinna, Laura and Nikita Ivanisenko.
May, 2020
Our joint manuscript 'The Recombinant Fragment of Human Κ-Casein Induces Cell Death by Targeting the Proteins of Mitochondrial Import in Breat Cancer Cells' has been accepted for the publication in 'Cancers'.
Congratulation to Max, Fabian and all our cooperation partners.
2019
December, 2019
Another of our manuscripts with the title 'Dissecting DISC regulation via pharmacological targeting of caspase-8/cFLIPL heterodimer' has been accepted in 'cell death and differentiation'.
Congratiulations again to Laura and Nikita Ivanisenko.
November, 2019
Our manuscript 'Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly.' has been accepted in 'Oncogene'.
Congratulations to Laura and our cooperation partner Nikita Ivanisenko.
September,25-27th, 2019
Our whole group took part in ECDO conference 2019 in Dresden. We have presented 5 posters and one invited talk.
July, 2019
We are delighted that the publication from our group has been highlighted at the Cover Image of the International Journal of Cancer:
https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.31691
Congratulations to Laura!
June, 2019
Corinna Koenig has won a fellowship from ECDO organization to attend the 27th ECDO conference on Cell Death.
Congratulations to Corinna!
May, 2019
Our group took again an active part in the 'Long night of Science' and we informed many interested visitors about our research. Furthermore, Max Richter has given a talk "Programmed Cell Death- live and let die".
January, 2019
Our cooperative manuscript 'Targeting RIPK1 in AML cells carrying FLT3-ITD mutation' has been accepted in the international Journal of Cancer.
Congratulations to Laura!
December, 2018
The organization of the trilateral Symposium has been highlighted by press release at Medical Faculty and Gesundheit-Sachsen-Anhalt:
http://www.med.uni-magdeburg.de/pressemitteilungen.html
https://www.gesundheit-sachsen-anhalt.de/de/wissenschaft/trilaterales-symposium-in-magdeburg-20058409.html
November, 30th 2018
Our group has run a trilateral Symposium 'From molecular-genetic networks to translational medicine', which was supported by Volkswagenstiftung. The symposium was attended by scientists from Germany, Ukraine, Russia and representatives of International affairs Office of DFG.
November, 28th 2018
The organization of ECDO by our group has been highlighted by press release at Medical Faculty, Magdeburger Volksstimme and Volksstimme-Wolmirstedt:
http://www.med.uni-magdeburg.de/Presse/Pressemitteilungen/Internationale+Experten+pr%C3%A4sentierten+neue+Erkenntnisse+zur+Erforschung+des+Zelltods.html
November, 27st 2018
Our rational molecular probes design story by Ivanisenko N.V., Buchbinder J.H. et al, 'Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes' is accepted for publication in BMC Genomics.
Congratulations to all co-author
November, 21st 2018
In the frames of the GBM-CDS minisymposium for the GBM-Master Prize for Corinna König, Corinna has given a lecture 'Targeting apoptotic pathway'. It was followed by the talk of Prof.Dr. Dirk Brenner, Luxembourg Institute of Health,'cROSroads between T cell function and metabolism.'
October, 2018
The organization of ECDO by our group has been highlighted by Press release at Medical Faculty, Volksstimme Magdeburg and Volksstimme Wolmirstedt:
http://www.med.uni-magdeburg.de/Presse/Pressemitteilungen/Internationale+Experten+pr%C3%A4sentierten+neue+Erkenntnisse+zur+Erforschung+des+Zelltods.html
October, 10th to 12th, 2018
Our group has served as one of three key organizers the 26th ECDO (European Cell Death Organization) conference 'From small molecules to translational medicine' in Saint-Petersburg, Russia.
Laura has given a talk 'Dissecting extrinsic cell death pathway via imaging flow cytometry' at ECDO2018.
Max has given a flash talk and a poster presentation 'Recombinant analogon RL2 of human κ-Casein induces cell death in breast cancer cells'.
Our cooperation partner Nikita Ivanisenko and Laura Hillert made a major contribution to the special ECDO 2018 announcement in the Nature group journal Cell Death and Differentation. This editors' pick highlighted a special focus of the meeting: small molecules. https://www.nature.com/collections/lqbxphbdjr/
September, 2018
Corinna König has received the "GBM Master Award of the OVGU" from the Society for Biochemistry and Molecular Biology. We congratulate Corinna on receiving this honorable Award and her graduation, and welcome her as a new PhD student in our group.
July, 2018
Our two cooperation manuscripts with Dennis Pischel and Robert Flassig on modeling cell fate in single cells are accepted on Plos and Plos Computational Biology.
Congratulations to Jörn!
June, 14th 2018
We took part on the 'Firmenstaffellauf' in Magdeburg, together with Hannes Bongartz and Heike Rummel as team 'FASt Blotters'. Our team was able to run the 5 x 3km in 1h 16 min and 45 sec and finished on place 137.
June 2018
Our group took an active part in the 'Long night of Science 2018'. Max Richter has given a talk "Programmed Cell Death- live and let die".
September, 8th to 11th 2017
Max Richter gave a talk in Lviv/Lemberg on trilateral meeting ‘Towards development of novel anti-cancer therapies’
June, 23rd 2017
Due to a severe storm the company running competition "Firmenstaffel Magdeburg" started one day later this year. Our spontanously reassembled team was able to run the 5x3 km in 1h 14 min and 38 sec and finished on the good 84th place in the mixed category.
November 2016
We thank our DAAD visitors 2016: Clara Wolfe (USA), Gelina Kopeina (Russia) and Alexey Zamaraev (Russia) for their great contribution to our projects!
July 2016
Our recently published manuscript on RIP1 networks in pancreatic cancer has been highlighted as "Global Medical Discovery"
June, 23rd 2016
We participitated the third time in the company running competition "Firmenstaffel Magdeburg" and were able to finished on the 126th place in the mixed category.
June, 6th 2016
Sabine gave a talk with the title "Life/death decisions in death receptor networks: new technologies and combinatorial treatment of pancreas cancer cells with gemcitabine and CD95L" at the CDS Progress Meeting.
May, 21st 2016
We took part in Lange Nacht der Wissenschaft. Jörn has given a talk " Progammed Cell Death - Live and let die"
May 2016
Nikita Ivanisenko from Institute of Cytology and Genetics; Novosibirsk visited Magdeburg and gave a presentation "Modeling CD95 pathway"
May 2016
Our manuscript “Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response" together with Dr. Christoph Zimmer (Yale School of Medicine; USA) recently published in Molecular Biosystems has been nominated to be a part of HOT article collection on Molecular Biosystems website. HOT article collection presents the top papers published in the journal.
April, 3rd to 8th 2016
Laura was at the EWCD and gave a presentation with the title "Evaluation of apoptotic target molecules for clinical therapy".
March, 14th 2016
Jörn gave a talk with the title "Imaging flow cytometry as a tool to understand life/death decisions and get new insights into death receptor networks" at the CDS seminar.
February 2016
Our collaborative project with the group of PD Dr. Ildiko Dunay "Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes" has been accepted for publication in Acta Neuropathologica Communications. Congratulations to Sabine!
January, 9th 2016
Sabine gave a talk with the title "Imaging flow cytometry as a tool to understand life/death decisions in death receptor networks" at the 1. Science Days of ÖGDV in Bad Aussee, Austria.
October, 29th 2015
Laura Hillert gave a talk with the title "Towards understanding cell death regulation in AML" at the house seminar of our building.
October, 6th 2015
The manuscript from our Group by Pietkiewicz et al., "Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network" has been accepted to journal of experimental cell research, congratulations to Sabine!
September 2015
Our collaborative project with the group of Prof. Dunja Bruder "Morphological and functional alterations of alveolar macrophages in a murine model of chronic inflammatory lung disease" has been accepted for publication in Lung. Congratulations to Sabine!
August, 13th 2015
Kirill Korneev, DRFZ/ Berlin - Moscow State University/ Moscow gave a talk with the title: "Novel aspects of Toll-like receptor 4 interaction with non-canonical lipopolysaccharides from various Gram-negative bacteria".
August, 3rd 2015
The manuscript from our Group "Molecular architecture of the DED chains at the DISC: Regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain" has been accepted for publication in Cell Death and Differentiation
July, 9th 2015
A team of our group participated successfully in the company running event "Firmenstaffel Magdeburg".
July, 6th 2015
Olga Popik and Evgeny Petrowsky from the Novosibirsk Institute of Cytology and Genetics were giving talks.
June, 22nd to 25th 2015
Dr. Kira Bettermann, Laura Hillert, Miriam Bollmann and Claudia Arndt participate in the 7th International Young Scientist School "Systems Biology and Bioinformatics" SBB-2015 in Novosibirsk.
May, 4th 2015
Our manuscript "Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/ propidium iodide staining" by Dr. Sabine Pietkiewicz, Jörn Schmidt and Prof. Inna Lavrik is accepted for a special issue on Imaging Flow Cytometry in the Journal of Immunological Methods. Congratulations to Sabine and Jörn!
May, 4th 2015
Our manuscript "Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level" by Jörn Schmidt, Dr. Sabine Pietkiewicz, Prof. Michael Naumann and Prof. Inna Lavrik is accepted for a special issue on Imaging Flow Cytometry in the Journal of Immunological Methods. Congratulations to Jörn and Sabine!
Science Night in Magdeburg
We will participate in this event on May the 30th.
January, 23rd 2015
Nikita Ivanisenko from the Novosibirsk Institute of Cytology and Genetics was giving a talk.
November, 6th 2014
Dr. Sabine Pietkiewicz has presented a novel method developed in our lab in the Nature Webcast "A closer look at cell death with imaging flow cytometry"
October, 16th 2014
Olga Saik, PhD student at the Institute of Cytology and Genetics, Novosibirsk, gave a talk with the title "Data-mining in molecular-genetic networks" in our seminar room.
October, 1st 2014
Olga Popik, PhD student at the Institute of Cytology and Genetics, Novosibirsk, gave a talk with the title "Analysis of molecular-genetic networks distributed over intracellular compartments based on protein-protein interactions" in room 027, building 28.
July, 7th 2014
The Department team together with supporters took part in the company run competition: "Firmenstaffel Magdeburg 2014".
May, 28th 2014
We moved to the new system biology building in building 28 / Pfälzer Platz. You can find our new telephone numbers here.