Understanding Life Through Systems

Life is complex—even at the molecular level. Every cell in our body operates within a dynamic cycle of function, death, and renewal. While classical molecular biology has provided invaluable tools, it often falls short of capturing the full depth of this complexity.

That’s where Systems Biology comes in.

What We Do

The Eastern German Systems Biology Network (EGSBN) connects researchers, institutions, and innovators to explore biological systems holistically. We study how cells make critical decisions—whether to divide, differentiate, or die—and how these are regulated by complex signaling networks.

By combining mathematical modeling, AI-powered analysis, and advanced experimental techniques, we seek to understand life not just as isolated parts, but as dynamic, responsive systems.

EGSBN is jointly directed by Prof. Inna Lavrik (Otto von Guericke University Magdeburg) and Prof. Lars Kaderali (University of Greifswald), both renowned leaders in systems biology and computational medicine.

Why It Matters

Cellular behavior isn’t black and white. Depending on the context—gene expression, protein abundance, network interactions—the same molecule can lead to drastically different outcomes.

Systems Biology helps us explain and predict such phenomena through:

• Feedback loops
• Stoichiometric control
• Bistability and thresholds

These principles guide our understanding of health, disease, and therapeutic opportunities.

Our Mission

We are building a collaborative and inclusive regional network to:

• Foster interdisciplinary research across Eastern Germany
• Support early-career scientists with training and mentorship
• Promote excellence in systems-level biological research
• Enable translation of discoveries into health and biotech innovation